TLC Test: The Total Leukocytes Count Test | An Overview


TLC Test

 TLC Test meaning or Tlc stands for Total Leukocytes Count.

Whenever you go to a doctor for a treatment, he/she sometimes advise some pathological tests.

After going through the test, while you receive the reports of your pathological tests, sometimes you have the curiosity to know that what your report says.

But, you cannot read the report with reason- just because of unknown medical terms, less knowledge of test’s normal value and what probable disease you might affect if the test value is other than normal, etc.

Don’t worry, hereafter read this blog you may overcome your curiosity and will find answers to most of your queries like:

What should the normal count of the test advise?

If your report’s value is above than normal:

What types of disease does it indicate?

Similarly, If your report’s value is lower than normal-

Which diseases it indicates and at what extent?

It is also an answer to your question that you sometimes asked either from yourself or from the doctor that why these tests are advised?

Out of various pathological tests, some tests are very common like test of  Tlc, Dlc in blood. Now the question is what is Tlc and Dlc in human body?

Here described TLC test, The Total Leukocytes Count or Tlc count in blood, a very common test recommended by almost every segment of doctors like -physician, pediatrician, gynecologists, Ent, Dermatologists, etc.


Tlc blood test

TLC test or Total Leukocytes count is a blood test that measures the number of White Blood Cells in the body. Leukocytes are white colored blood cells which protect our body against infection and diseases.

They may decrease in number in certain disease making the body prone to infection. TLC test also helps to diagnose any acute (short period of time) or chronic (long period of time) infection.

The key function of WBC is to fight against bacterial, viral, fungal and parasitic infections. The Normal range value in TLC test varies as per age:


0-24 Hrs 9000-38000 cells/cu-mm
24hrs-1week 5000-34000 cells/cu-mm
01 week- 6 months 5000-21000 cells/cu-mm
06 month- 4yrs 5500-17500 cells/cu-mm
04yrs- 14yrs 4500-15500 cells/cu-mm
14yrs-21yrs 4500-13200 cells/cu-mm
>21yrs 4000-11000 cells/cu-mm

NOTE: Please note, normal range values differ from one pathology lab to another.


high Tlc count


The diseases/ infection/ medicines may cause TLC count low, are:

  • Viral/ bacterial Infection:   Infection caused by virus or bacteria
  • Liver and spleen disease:   An enlarged spleen can be caused by infections, cirrhosis and other liver diseases and leads to  affect TL count
  • Autoimmune disorder:       A condition in which your immune system mistakenly attacks your body
  • Chemotherapy for cancer: A method to treat cancer
  • Anti-Thyroid medicines:   Anti-Thyroid medicines also lowering TLC
  • Due to Antibiotics:            Some antibiotics also lowering Tlc
  • Captopril:                          A medicine used for lowering high blood pressure
  • Clozapine:                         A drug that affects blood pressure
  • Sulphonamides:                 Drug used in Urinary Tract Infections
  • Terbinafine:                       Drug used in Fungal Infection
  • Chlorpromazine:                A drug that thought to modulate dopamine and treat hiccups.
  • Ticlopidine:                       A drug is used for the prevention of strokes
  • Anticonvulsants:               Used in the treatment of epileptic seizures
  • Histamine 2blocker:          Used to treat duodenal ulcer
  • Quinidine:                         This medication is used to treat or prevent many types of irregular heartbeats
  • Arsenicals:                         A drug or preparation containing arsenic, a type of poison
  • Diuretics:                           Medicines that designed to increase the amount of water and salt expelled from the body
  • Bone marrow dysfunction due to tumor/fibrosis: Bone marrow dysfunction makes abnormal white blood cells, hence lowering its count
  • Radiotherapy for cancer:    It is similar to that of chemotherapy. In this situation, you could experience a low WBC count and even neutropenia
  • Bone marrow damage from cancer: Chemotherapy kills many of the WBC 


high Tlc count

If your TLC test is showing high TLC count in blood, it may be due to several reasons.  Some common reasons for the elevated Tlc count are :

  • Bacterial infections:                  Some bacterial infections cause high Tlc count
  • Leukaemia:                                It is cancer that affects the blood and bone marrow where blood cells are made.
  • Due to steroids:                         Steroids (Glucocorticoids- dexamethasone, prednisone) are known to increase the white blood cell (WBC) count
  • Beta-agonists:                            are medicines that relax muscles of the airways
  • Inflammatory disorders:            Increases WBC e.g. Allergy
  • Tissue damage:                          Limit injury or tissue damage initiates healing by increasing white blood cells count
  • Burns:                                        burns leads to an increase in the Tlc value 
  • Anaemia                                  less hemoglobin than normal in blood
  • Severe physical or

psychological distress: Is a key determinant of low-grade inflammation as represented by increases of WBC

  • Albuterol:                                  A bronchodilator that relaxes muscles  and eases breathing
  • Epinephrine:                              A medication and hormone
  • Lithium:                                     Drug used as psychiatric medication
  • Heparin:                                     Is an anticoagulant (blood thinner) that prevents the formation of blood clots.

So, now if a doctor advises you for TLC test, you can judge the importance of this test by matching with the symptoms in you or in your loved ones.

Also, you can co-relate the probable disease as according to your Tlc count or white blood cell count range.





[All information and content in this site are for information and educational purposes only. The information should not be used for diagnosis purpose for any health-related problem. Always consult with a qualified doctor for an expert diagnosis.]




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