Methergine Or Methylergonovine | Uses & Side Effects

Methergine Uses & Side Effects


Methergine (methylergonovine maleate or Methylergometrine) is a semi-synthetic ergot alkaloid.

It is used for the prevention and control of postpartum hemorrhage, Methergine affects the smooth muscle of a woman’s uterus, help control bleeding, improving the muscle strength, tone and timing of uterine contractions.

Methylergonovine is used just after the childbirth.

Methergine Uses

For control of uterine hemorrhage (postpartum bleeding)  in the second stage of labor.

Do not use Methergine in higher or lower amounts or for longer than recommended. Follow the directions on your prescription, given by your doctor.

Methergine injection can be used either into a muscle(IM) or into a vein through an Intravenous(IV) route. If needed, you will receive this injection just after your baby is born.

Methergine oral tablet is taken by mouth 3 or 4 times daily for up to 1 week after your baby is born.

Methergine uses other than dosage prescribes by your doctor, may harm you. Do not continue the tablet for more than a week, without your doctor’s consultation.

Methergine Abortion

Methergine makes blood vessels constrict throughout the body. Thus Methergine uses after abortion or a miscarriage to control uterine bleeding. Methylergonovine makes the uterus contract, which helps control blood loss.

Methergine Mechanism Of Action


This medication is used after baby birth to help stop bleeding from the uterus. Medically this term is known as postpartum hemorrhage.

Methergine Mechanism Of Action is to increase the frequency, strength of contractions and the stiffness of the uterus muscles. This process helps to decrease bleeding.

Methergine Side Effects

An allergic reaction like hives, difficulty in breathing, swelling on your face, lips, tongue, or throat is the Methergine Side Effects.

Call the medical help if you have seen any of these signs. Some common side effects of methergine may include:

  • Nausea, mild stomach pain or vomiting, diarrhea;
  • Increased sweating, mild skin rash;
  • Leg cramps;
  • A mild headache, dizziness;
  • Ringing in your ears;
  • Stuffy nose; or
  • Unpleasant taste in your mouth.

Besides these some serious side effect of Methylergonovine are:

  • Pain, swelling, warmth, or redness under your skin;
  • Seizure (convulsions);
  • Feeling like you might pass out;
  • Fluttering or pounding heartbeats or in your chest;
  • Slow heart rate, trouble breathing;
  • Blood in your urine;
  • Severe weakness, muscle cramps, confusion, slurred speech, fainting;
  • Hallucinations;
  • Heavy feeling in chest or pain, spreading to the shoulder or arm, nausea, sweating or general ill feeling;
  • Sudden numbness or weakness, especially on one side of the body;
  • Sudden severe headache, confusion, problems with vision, speech, or balance;
  • Pain, swelling, warmth, or redness in one or both legs; or
  • Severe high blood pressure (a headache, buzzing in your ears, confusion, blurred vision, anxiety, shortness of breath, uneven heartbeats, chest pain, seizure).

This is not a complete list of methergine side effects. Call your doctor for medical help if other than these side effects have seen.

 Methergine Contraindications

You should not use this medication if you have:

  • high blood pressure;
  • toxemia of pregnancy; or
  • if your baby has not yet been born.

Inform your doctor before you receive methylergonovine if you are suffering with:

  • liver or kidney disease; or
  • family history or risk factors for coronary artery disease, diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol.

Methylergonovine should not be used during your pregnancy. This medication is to be used only after the birth of your child.

Breastfeeding to the baby is not recommended within 12 hours after taking Methergine. It may pass into breast milk in small amounts and could harm your nursing baby.

In few cases, this medication can be continued for a week after consultation with your doctor.

Methergine affects your milk flow, thus You may need to use a breast pump to maintain your milk flow until your Methergine treatment is over.

Throw out any milk you collect during this period. Do not feed it to your baby.

Methergine may contraindicate with Grapefruit and grapefruit juice and lead to potentially dangerous effects.

Consult with your doctor for the use of grapefruit products. Other medicinal methergine contraindications are with:

  • Nefazodone;
  • Antifungal Medicine
  • Hepatitis C Medicines
  • HIV Or AIDS Medicines

Methergine Dosage 

Methergine injection can be given either into a muscle or into a vein through an IV. If needed,  You will receive this injection just after your baby is born.

Methergine oral is a tablet taken by mouth 3 or 4 times daily for up to 1 week after your baby is born. Do not take Methergine other than dosage prescribe by your doctor.

Methylergonovine should not be used for longer than 1 week or without prescription by your doctor.

What To Do If Dosage Missed?

If the dose is missed, take it as soon as you remember within few hours. But, if it is almost time for your next scheduled dose, skip the previous one.

Do not take extra medicine to make up the missed dose.

Methergine OverDosage                              

Methergine overdose symptoms may include:

  • Vomiting,
  • Stomach Pain,
  • A throbbing Headache,
  • Numbness Or
  • Tingling In Your Fingers Or Toes,
  • Cold Feeling,
  • Weak Or Shallow Breathing, Or
  • Seizure (Convulsions)
Methergine Brand Names 
  • Methergine (Novartis)
  • Uterine (Svizzera)
  • Metformin (Cadila)
  • Erdogan (Cipla)
  • Ergoline (Lincoln)
Methergine Storage

Store at room temperature i.e. at 250 C  and keep away from moisture, heat, and light.

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